General

This is my go-to loadout to fight groups of enemies. It has very strong AoE Fire DoT damage which allows you to take down multiple enemies at once.
The self-healing from the Heelepoort guns ensures you can survive attacks from multiple enemies.

Weapons

Front and Sides

I choose the Hellepoort Culverines as they synergize well with the Sambuke Fire perks as well as providing a good amount of self-healing, which is required when taking up groups of enemies. For perks we concentrate to up the fire damage as well as the self-healing.

Back

On the back I am using the Hellgate Serpent. It provides the same fire and self-healing perks as the Heelepoort guns, has good range and better damage than the Nashkar guns, which could also be an option here.

###Auxilary
Infernal Maw is my choice here as a single buoy can trigger the ablaze status effect and in turn the Sambuke Perk "Scorched", setting all enemies ablaze that are close enough to each other.

###Armor
Buccaneer's Oath is the go-to choice here as is gives us a massive boost to our damage and armor. All perks are focused to up our armor to benefit even more from the 25% increase.

Other Informations

Attack Rotation:
Attack with Crouching Tiger to ablaze the enemy and spread the ablaze to all nearby enemies. Smaller ships will burn down to death already. Ships with a bit more health can be further attacked with the Hellepoort guns.